Hypoxia-inducible factor-1α in stem cell preconditioning: Mechanistic role of hypoxia-related micro-RNAs

Role of hypoxia-inducible factor-1α in autophagic cell death in microglial cells induced by hypoxia

Microglial cells are phagocytic cells of the central nervous system (CNS) and have been proposed to be a primary component of the innate immune response and maintain efficient CNS homeostasis. Microglial cells are activated during various phases of tissue repair and participate in various pathological conditions in the CNS. Following spinal cord injury (SCI), anoxemia is a key problem that resu...

Role of hypoxia-inducible factor-1α in preconditioning-induced protection of retinal ganglion cells in glaucoma

PURPOSE We recently demonstrated in a mouse model of glaucoma that endogenous epigenetic mechanisms can be activated by a repetitive hypoxic preconditioning (RHP) stimulus to provide robust retinal ganglion cell (RGC) protection. Although we also provided evidence that RHP prevents or delays the apoptotic demise of the RGC soma, the mechanisms responsible for signaling this epigenetic response,...

The role of hypoxia inducible factor 1α in diabetic cardiomyopathy

Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmania...

Role of Hypoxia-inducible Factor-1 Alpha in Neural Stem/progenitor Cell Function following Hypoxia By

OF DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Biomedical Sciences The University of New Mexico Albuquerque, New Mexico